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目的 评价艾司洛尔和胺碘酮联合用药方式治疗老年室性心律失常的临床效果和安全性。方法 将2018年1月至2019年8月在我院治疗的58例室性心律失常患者按照随机方法分为观察组和对照组，每组29例。观察组行艾司洛尔联合胺碘酮治疗，对照组行常规胺碘酮治疗，分别计算两组相关数据统计结果，并做统计学比较。结果 ①经统计，观察组治疗有效率为96.55%（28/29），对照组为72.41%（21/29），有统计学差异（P＜ 0.05）。②观察组患者的1个月内，复发率和并发症发生率都普遍低于对照组，有统计学差异（P＜0.“,”Objective To evaluate the clinical efficacy and safety of esmolol and amiodarone in the treatment of ventricular arrhythmia in the elderly. Methods Fifty-eight patients with ventricular arrhythmia who were treated from January 2018 to August 2019 in my hospital were randomly divided into observation group and control group， with 29 cases in each group. The observation group was treated with esmolol combined with amiodarone， and the control group was treated with conventional amiodarone. The statistical results of the two groups were calculated and statistically compared. Results (1)According to statistics， the effective rate of treatment in the observation group was 96.55% (28/29)， and the control group was 72.41% (21/29). There was a statistical difference (P＜0.05). (2)One of the patients in the observation group Within months，the recurrence rate and complication rate were generally lower than those of the control group， with statistical differences (P＜0.05). (3)The ECG indicators of the two grousof patients before treatment were not statistically significant (P＞0.05)， after treatment the QTcd of the two groups was improved compared with the heart rate level and before treatment， but the improvement effect of the observation group was better than that of the control group， and there was a statistical difference (P＜0.05). (4)Before treatment， the left ventricle of the two groups of patients There was nosignificant difference in ejection fraction， left ventricular end-diastolic volume， left ventricular end-systolic volume， etc. (P＞0.05). After treatment，left ventricular ejection fraction， left ventricular end-diastolic volume， and left ventricular end-systolic volume of the two groups of patients Equally improved， but the improvement effect of patients in the observation group was better， with a statistical difference (P＜0.05). (5)The improvement effect of systolic and diastolic blood pressure levels in the observation group after treatment was better than that of the control group， with statistics Academic difference (P＜0.05). Conclusion The effect of esmolol combined with amiodarone in the treatment of elderly patients with ventricular arrhythmia is better than that of conventional single amiodarone. It can adjust the ECG indexes of patients， enhance the cardiac function of patients，optimize the blood pressure level of patients， reduce the recurrence rate of patients， obtain better safety， improve the clinical indexes， and is worthy of popularization.