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目的:观察长期应用国产小剂量辛伐他汀结合调整给药方法对高脂血症患者治疗的有效性及安全性。方法:选择我院所服务的社区自愿接受他汀治疗的高脂血症患者,给予国产辛伐他汀10 mg·d-1,每晚1次顿服,每月服20 d,停10 d,循环往复,其中36例服药3~24个月;分析治疗前后血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、天门冬氨酸氨基转移酶(ALT)、肌酸激酶(CK)变化。结果:治疗后TC、TG、LDL-C等水平较治疗前下降,差异有统计学意义(P<0.05),ALT、CK水平治疗前后无改变(P>0.05)。结论:调整国产小剂量辛伐他汀治疗方法后,高脂血症患者在一定程度达标的状态下,可达到长期调脂的目的,兼顾了效益—费用—风险,且患者服药依从性良好。
Objective: To observe the effectiveness and safety of long-term domestic small-dose simvastatin combined with adjusted administration in patients with hyperlipidemia. Methods: Sixty patients with hyperlipemia who volunteered with statins in the community served by our institute were given domestic simvastatin 10 mg · d-1, once a night for a day, and served for 20 days a month for 10 days. 36 patients were given drugs for 3 to 24 months. The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), aspartate aminotransferase Creatine kinase (CK) changes. Results: After treatment, the levels of TC, TG, LDL-C decreased compared with before treatment, the difference was statistically significant (P <0.05). ALT and CK levels did not change before and after treatment (P> 0.05). Conclusion: After the adjustment of the domestic low-dose simvastatin treatment, patients with hyperlipidemia can reach the goal of long-term lipid-lowering with a certain degree of compliance, taking into account the benefit-cost-risk and good compliance of the patients.