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目的 研究多次小剂量放射免疫治疗 (RIT )对肿瘤小体积转移灶的预防和治疗作用及使用安全性。方法 采用高转移率的LA 795肺腺癌小鼠模型。比较在第 8天或第 15天施行肿瘤原发灶切除后分别给予分次小剂量RIT、化疗、单次大剂量RIT的抑瘤效果。观察正常小鼠放射免疫治疗后体重、外周血白细胞和血小板的改变及主要器官组织病理改变。结果 不同手术时间的综合治疗均显示 ,分次小剂量RIT组小鼠生存期延长 ,肺转移灶数减少 (分别有 3例和 2例无转移 ) ,疗效优于其它各组 (P<0 .0 5 )。提早手术并分次小剂量放射免疫治疗的疗效更佳 (P <0 .0 5 )。大、小 2种剂量131I C5 0对小鼠的白细胞、血小板的数量无显著影响 ;对骨髓及其它重要器官无明显的抑制和辐射损伤。结论 分次小剂量RIT优于化疗 ;提前手术加分次小剂量RIT疗效更优 ;131I C5 0小剂量放射免疫治疗是安全的。
Objective To study the preventive and therapeutic effects and safety of multiple low-dose radioimmunotherapy (RIT) on tumor volume metastasis. Methods High metastatic LA 795 lung adenocarcinoma mouse model was used. The tumor-inhibiting effect of small dose RIT, chemotherapy and single high-dose RIT was compared on the 8th day or the 15th day after resection of the primary tumor. The normal mice were observed after radioimmunotherapy weight, peripheral blood leukocytes and platelet changes and major organ histopathological changes. Results The comprehensive treatment of different operation time showed that mice in fractionated low-dose RIT group had longer survival period and fewer lung metastases (3 cases and 2 cases without metastasis, respectively), which was superior to other groups (P <0. 0 5). Early surgery and small doses of radioimmunotherapy with better efficacy (P <0. 05). Large and small doses of 131I C5 0 had no significant effect on the numbers of white blood cells and platelets in mice, and no obvious inhibition on the bone marrow and other vital organs and radiation injury. Conclusions The small dose of RIT is better than chemotherapy. The preoperative and postoperative low dose RIT is more effective. Low dose 131I C5 0 radioimmunotherapy is safe.