Infliximab治疗传统疗法效果不佳的成年人中重度Crohn’s病 (CD)已显示临床疗效 ,可能是抑制了粘膜炎性病变过程。现报道首次应用 infliximab治疗青少年 CD的临床经验。资料与方法　对美国三个儿童炎性肠病治疗中心用infliximab治疗的 19例 CD患儿进行复习。对传统疗法无效或效 Severe Crohn’s disease (CD) in Infliximab in adults who are not well treated with conventional therapies has been shown to have clinical efficacy that may have inhibited mucosal inflammatory processes. We report the first clinical trial of infliximab in the treatment of adolescent CDs. Materials and Methods Nineteen CD infants treated with infliximab were reviewed in three U.S. pediatric inflammatory bowel disease treatment centers. Traditional therapy invalid or effective