以死亡为指标，根据药物累积法原理测定了小鼠口服及腹腔注射川芎挥发油的表观药动学参数。结果：ＬＤ５０（ｉｐ）＝５１７．５１±９０．０１ｍｇ／ｋｇ，按２９０ｍｇ／ｋｇ剂量ｉｐ给药，其体存药量的表观药动学过程符合一室开放模型，Ｋｅ＝０．４６６ｈ１，ｔ１／２（ｋｅ）＝１．５ｈ。ＬＤ５０（ｉｇ）＝２９８２．３７±３４５．１２ｍｇ／ｋｇ，按１５４８ｍｇ／ｋｇ剂量ｉｇ给药，其体存药量的表观药动学过程符合一室开放模型，Ｋｅ＝０．２４６ｈ１，ｔ１／２（ｋｅ）＝２．８ｈ。口服给药相对生物利用度为１７５０％。 Taking death as an index, the pharmacokinetic parameters of volatile oil of Ligusticum chuanxiong Hort.f. Were determined in mice by the principle of drug accumulation. Results: The apparent pharmacokinetics of LD50 (ip) = 517.51 ​​± 90.01 mg / kg and ip at 290 mg / kg were consistent with the one-compartment open model with Ke = 0.466 h 1, t1 / 2 (ke) = 1.5h. LD50 (ig) = 2982.37 ± 345.12mg / kg, according to the dose of 1548mg / kg ig administration, the apparent pharmacokinetic process of the body storage dose in line with the open chamber model, Ke = 0.246h 1, t1 / 2 (ke) = 2.8h. The relative bioavailability of oral administration was 1750%.