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新生儿细菌性脓毒症是一种威胁生命的疾病,每1000活产中约有1～10个患者发生本病。其病死率为20～75%,病死率高低取决于细菌、宿主的免疫活性和诊断时存在的有关并发症。本病的最后结局取决于许多因素,包括新生儿就医时的免疫、生理状态和成熟度,容易导致感染的围产期疾病的存在,及侵入性支持性治疗措施(如血管导管)的应用。早期诊断和早期开始适当的抗生素治疗及处理代谢和呼吸问题也可大大影响本病的结局。在免疫学上,新生期动物及人的宿主防御
Neonatal bacterial sepsis is a life-threatening condition that occurs in about 1 to 10 patients per 1000 live births. The case fatality rate is 20-75%. The mortality depends on the bacteria, the immune activity of the host and the complications associated with the diagnosis. The final outcome of this disease depends on many factors, including the immunization, physiology and maturity of the newborn, the perinatal conditions that predispose to infection, and the use of invasive supportive treatments such as vascular catheters. Early diagnosis and early initiation of appropriate antibiotic treatment and management of metabolic and respiratory problems can also greatly affect the outcome of this disease. Immunologically, neonatal animal and human host defense