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人参茎叶皂甙(Ginsensides of the stem and leaf of panax Ginseng, GSL)50毫克/公斤体重腹腔和静脉给药,均增加麻醉豚鼠哇巴因LD_(100)剂量(毒性降低);人参茎叶皂甙50毫克/公斤体重静脉注射,降低麻醉猫动脉压(AP)、左室内压(LVP)、心室内压上升最大速率(dp/dt max),心输出量(CO)有所增加,其他心功指标无明显影响。由于AP、LVP、dp/dt max降低,使TTI减少,提示心肌耗氧量降低,为临床治疗高血压、冠心病、心源性休克等循环系统疾病提供药理学基础。
Ginsenosides of the stem and leaf of panax Ginseng (GSL) 50 mg/kg body weight both intraperitoneally and intravenously increased the dose of ouabain LD 100 in anaesthetised guinea pigs (lower toxicity); Ginsenoside 50 Intravenous injection of mg/kg body weight decreased the cat arterial pressure (AP), left ventricular pressure (LVP), maximum intraventricular pressure elevation (dp/dt max), and cardiac output (CO) increased. Other heart function indicators No significant effect. Due to the decrease of AP, LVP, and dp/dt max, the TTI is reduced, which indicates that myocardial oxygen consumption is reduced, providing pharmacological basis for clinical treatment of hypertension, coronary heart disease, cardiogenic shock and other circulatory diseases.