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采用随机对照方法对４３例中重度慢性心力衰竭患者服用血管紧张素转换酶抑制剂（ＡＣＥＩ）前后的心率变异性（ＨＲＶ）进行分析，评估服用ＡＣＥＩ对慢性心衰患者的自主神经调节功能及自主性平衡的影响。结果发现，对照组和治疗组在基线期末自主神经的活性无显著差异，但经３～６个月治疗后，治疗组的时域变量和频域变量均呈显著性提高：ＳＤＮＮ从８１．７±２８．９升至９６．０±３０．３（ｍｓ，Ｐ＜０．００１）；ＳＤＡＮＮ从６６．８±２４．５升至８３．２±３２．２（ｍｓ，Ｐ＜０．００１）；ｒＭＳＳＤ从４４．４±１２．４升至６０．６±１５．４（ｍｓ，Ｐ＜０．０１）。频域变量２４ｈ自然对数值均值：ＬＦ从４．５９±１．０３升至５．０９±１．２０（Ｐ＜０．０１）；ＨＦ从５．０７±０．８７升至５．６７±０．９１（Ｐ＜０．００１）；ＴＰ从６．４４±０．８２升至６．８４±０．９４（Ｐ＜０．０１）。表明长期服用ＡＣＥＩ可使心衰患者受损的自主神经调节功能及自主性平衡得以恢复。
A randomized controlled trial was conducted on heart rate variability (HRV) in 43 patients with moderate-to-severe chronic heart failure before and after taking angiotensin-converting enzyme inhibitor (ACEI) to evaluate the effect of ACEI on autonomic nervous system function and autonomic The impact of sexual balance. The results showed that there was no significant difference in the activity of autonomic nerve between the control group and the treatment group at the end of baseline, but after 3 to 6 months treatment, the time-domain variables and frequency-domain variables of the treatment group showed significant improvement: SDNN increased from 81.7 ± 28.9 to 96.0 ± 30.3 (ms, P <0.001); SDANN increased from 66.8 ± 24.5 to 83.2 ± 32.2 (ms, P <0.001) ; RMSSD increased from 44.4 ± 12.4 to 60.6 ± 15.4 (ms, P <0.01). The natural logarithmic mean value of the frequency-domain variables was 24h: LF increased from 4.59 ± 1.03 to 5.09 ± 1.20 (P <0.01); HF increased from 5.07 ± 0.87 to 5.67 ± 0.91 (P <0.001); TP increased from 6.44 ± 0.82 to 6.84 ± 0.94 (P <0.01). That the long-term use of ACEI can make patients with heart failure impaired autonomic nervous system regulatory function and autonomic balance restored.