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肌苷作为一种次黄嘌呤、核苷制剂.临床上多用于治疗心功能不全白细胞减少.近年又有新用途发现。l顽固性蛋白尿有人用大剂量肌苷静滴治疗10 例,其中肾病综合征7例,慢性肾炎2例,尿毒症1例.全部病例用药前均经过4～6wk以上的强的松或加用细胞毒药物治疗而无效.方法;肌苷2.5～3g加入0.56mol·L~(-1)(10%)葡萄糖液中静滴.7d—疗程。本组用药前尿蛋白+++～++++者8例.++者2例。用肌苷3个疗程后尿蛋白±～+者9例.另一例尿毒症患者尿蛋白仍++～+++,用药前后疗效时比差异有显著性。
Inosine as a hypoxanthine, nucleoside preparation, clinically used to treat cardiac insufficiency leukopenia. In recent years, there are new uses found. l stubborn proteinuria Some people with high-dose intravenous infusion of inosine 10 cases, of which 7 cases of nephrotic syndrome, chronic nephritis in 2 cases, uremia 1. All cases before treatment after more than 4 ~ 6wk of prednisone or plus With cytotoxic drugs and ineffective. Methods; Inosine 2.5 ~ 3g added 0.56mol · L -1 (10%) glucose solution intravenously .7d-treatment. This group before treatment, urinary protein +++ ~ ++++ in 8 cases. ++ in 2 cases. With inosine 3 courses of urinary protein ± ~ + 9 cases.Another patients with urinary proteinuria still ++ ~ +++, before and after treatment than the difference was significant.