论文部分内容阅读
喜树碱（ＣＰＴ）是存在于中国喜树的天然生物碱，拓扑替康（ｔｏｐｏｔｅｃａｎ，ＴＰＴ）则是半合成的ＣＰＴ水溶性衍生物，它们都是ＤＮＡ拓朴异构酶的强烈抑制剂。ＣＰＴ具有广泛的抗肿瘤活性。ＣＰＴ和ＴＰＴ含有α－羟基－δ－内酯环，可发生与ｐＨ相关的可逆性水解，形
CPT is a natural alkaloid present in Chinese camptotheca acuminata and Topotecan (TPT) is a semisynthetic CPT water-soluble derivative, both of which are strong inhibitors of DNA topoisomerase. CPT has a wide range of anti-tumor activity. CPT and TPT contain alpha-hydroxy-delta-lactone rings that undergo reversible hydrolysis associated with pH,