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应用冠状动脉钙评分评估无症状的白人之间动脉粥样硬化负担的差别,其居住地心血管疾病发病率不同。巴西和葡萄牙白人有着类似的遗传基因,因而他们提供了环境因素对动脉粥样硬化进程影响的评价条件。研究回顾了17563位美国人、巴西人和葡萄牙人的冠状动脉钙评分数据,80%和88%的葡萄牙男性和女性的冠状动脉钙评分为0,相比而言,46%和62%的巴西男性和女性,33%和59%的美国男性和女性冠状动脉钙评分为0。研究显示,虽然美国人危险因素的患病率最低,但是他们的冠状动脉钙评分比巴西和葡萄牙组的中位数(四分位数之间)要高。经过校正心血管危险因素和年龄差别后,美国男性冠状动脉钙评分相对危险度比巴西或葡萄牙男性高。巴西和美国女性的冠状动脉钙评分危险度基本相同,但她们比葡萄牙女性的危险度高一些。在这个研究中,3个国家不同大洲之间冠状动脉钙评分的差别具有统计学意义。冠状动脉钙评分的差异和各自的心血管病死亡率相平行。
Coronary artery calcium score was used to assess the difference in atherosclerosis burden among asymptomatic whites with varying incidence of cardiovascular disease at home. Brazil and Portugal have similar genetic white genes, so they provide an assessment of the impact of environmental factors on the progression of atherosclerosis. The study reviewed coronary calcium scoring data from 17,563 Americans, Brazilians and Portuguese, with coronary calcium scores of 0% in 80% and 88% of Portuguese men and women, compared to 46% and 62% in Brazil Male and female, 33% and 59% of the United States male and female coronary calcium score of 0. Studies show that while Americans have the lowest prevalence of risk factors, their coronary calcium score is higher than the median (between quartiles) in Brazil and Portugal. After adjusting for cardiovascular risk factors and age differences, the relative risk of coronary calcium in the United States was higher in men than in Brazil or Portugal. Women in Brazil and the United States have similar risk of coronary calcium scoring, but they are at a higher risk than women in Portugal. In this study, the differences in coronary calcium scores across the three continents were statistically significant. Differences in coronary artery calcium scores were parallel to their respective cardiovascular mortality.