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采用改良法制备了４０例活检淋巴结染色体标本，有３５例获得满意分裂相。分析结果表明：淋巴结良性疾患的染色体以正常二倍体为主；恶性淋巴瘤（ＭＬ）实体瘤染色体均失去正常核型，其数目及结构畸变明显，可涉及至６，１４，８，３，１１，１８，１，１３号等染色体。在反复出现的８个标记染色体中，如１４ｑ＋，ｔ（１１；１４），ｔ（８；１４），ｔ（１４；１８），ｄｅｌ（１）（ｐ１３—ｔｅｒ），１３ｑ＋等，有４个组成与１４号染色体有关，提示１４ｑ３２的断裂重排与ＭＬ的发生可能有关；在何杰金病（ＨＤ）中ｄｅｌ（１）（ｐ１３－ｔｅｒ），１３ｑ＋出现较多，提示１ｐ１３，１３ｑ３３的断裂重排可能与ＨＤ的发生存在一定关系。
40 cases of biopsy lymph node chromosome specimens were prepared by modified method, and 35 cases obtained satisfactory schizonts. The results showed that the chromosomes of lymph node benign disease were mainly normal diploid. The chromosomes of malignant lymphoma (ML) solid tumors all lost their normal karyotypes, and their number and structure aberrations were obvious, which could involve up to 6, 14, 8, 11,18,1,13 and other chromosomes. Among the 8 repeated marker chromosomes, there are 4 such as 14q +, t (11,14), t (8,14), t (14,18), del (1) (p13-ter) The recombination was related to the chromosome 14, suggesting that the 14q32 rearrangement may be related to the occurrence of ML. In Hodgkin’s disease (HD), there are more del (1) (p13-ter) and 13q +, indicating the breakage of 1p13 and 13q33 Rearrangement may be related to the occurrence of HD.