临床上治疗缺氧缺血性脑病(Hypoxicischemic encephalopathy,HIE)时,在疾病极期多采用综合治疗措施,即在维持体内环境稳定的基础上对症治疗以保证各脏器功能正常,同时给以适当的针对病因干预,后者已成为目前研究的主导方向,本文将之综述如下。 1 药理学干预 已有多方面报道指出自由基清除剂、兴奋性氨基酸受体拮抗剂、钙离子通道阻滞剂、一氧化氮(NO)生成抑制剂作用于相应环节阻止HIE发病,还有一些药物干预措施已证明对HIE有 Clinically, Hypoxicischemic encephalopathy (HIE) is clinically used for the treatment of HIE. In the extreme stage of the disease, comprehensive treatment is used, which is symptomatic treatment based on the maintenance of environmental stability in the body to ensure the normal functioning of various organs, For the cause of intervention, the latter has become the dominant direction of the current study, this article will be summarized as follows. A pharmacological intervention has been reported in many aspects that free radical scavengers, excitatory amino acid receptor antagonists, calcium channel blockers, nitric oxide (NO) production inhibitors in the corresponding part of the prevention of HIE pathogenesis, there are some Drug interventions have been shown to have HIE