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高度纯化的牛真皮胶原制剂最近已用于治疗皮肤外形缺陷的病人。按照产品的说明,有自身免疫性疾病病史者为牛胶原移植的禁忌症,但是对于自身免疫性疾病与胶原移植副反应之间的关系以及牛胶原植入使原来存在的自身免疫疾病恶化的可能性,仍了解很少。作者采用一种酶联免疫吸附测定法,检查了50例结缔组织病患者(包括硬皮病、类风湿性关节炎和系统性红斑狼疮)血清中抗牛胶原植入物抗体,这些病人均未接受牛胶原植入。同时采集117例正常人血清作为对照。
Recently, highly purified bovine dermal collagen preparations have been used in the treatment of skin defect patients. According to the product description, there is a history of autoimmune diseases contraindications for bovine collagen transplantation, but the relationship between autoimmune diseases and the side effects of collagen transplantation and bovine collagen implantation may worsen the existing autoimmune diseases Sex, still little understanding. Using an enzyme-linked immunosorbent assay, the authors examined anti-bovine collagen implants in sera from 50 patients with connective tissue disease (including scleroderma, rheumatoid arthritis and systemic lupus erythematosus), none of these patients Accept bovine collagen implantation. At the same time, 117 normal human serum was collected as a control.