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骨转移瘤是晚期肿瘤常见的并发症,以肺癌、乳腺癌、前列腺癌、胃癌等最为常见。骨转移可造成溶骨性结构破坏而引起剧烈疼痛、功能障碍甚至病理骨折,严重影响患者的生活质量。因此止痛成为恶性肿瘤骨转移患者的主要治疗问题[1]。近年来用抗骨溶解制剂双膦酸盐类逆转溶解病变的进
Bone metastases are common complications of advanced cancer, with lung cancer, breast cancer, prostate cancer, stomach cancer and other most common. Bone metastasis can cause osteolytic destruction of the structure and cause severe pain, dysfunction and even pathological fractures, seriously affecting the quality of life of patients. Therefore, painkillers become the main treatment of patients with malignant tumor bone metastases [1]. In recent years with anti-osteolytic bisphosphonate reverse dissolution lesions into