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病因病原体及其毒素近年来,感染性疾病的病原菌种变动较大:耐药性金葡菌,因β-内酯环系抗菌素的发展而有所减少;而固紫阴性杆菌(GNB)的感染,却明显增多。GNB大多是正常与人体共生的非致病菌,内源性感染的发生主要由于机体防御功能薄弱。老年人多、皮质激素、抗癌和抗代谢药物的广泛应用,手术范围扩大等等,都使对GNB易感的人群增加。另一方面,GNB对一般抗菌药物多有不同程度的天然耐性;而且由于抗菌素的广泛应用,耐药菌株更有所增多,而目前对GNB强有力的抗菌药物还较少,难以迅速控制其感
Pathogenic pathogens and their toxins In recent years, pathogenic strains of infectious diseases vary greatly: drug-resistant Staphylococcus aureus, decreased due to the development of β-lactone ring antibiotics; and the infection of solid-negative bacilli (GNB) , But significantly increased. GNB are mostly non-pathogenic bacteria that normally coexist with human body. The occurrence of endogenous infections is mainly due to the weak defense function of the body. Many elderly people, corticosteroids, anti-cancer and anti-metabolic drugs are widely used, the scope of the operation to enlarge, etc., are susceptible to GNB increased population. On the other hand, GNB has many degrees of natural tolerance to general antimicrobial agents. Moreover, due to the wide application of antibiotics, more resistant strains are more increased, and currently, there are few powerful antimicrobial agents against GNB and it is difficult to quickly control their effects