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自口服利尿-降压药氯噻嗪(chlorothiazide,簡称CT)问世以来,国內外研究者都对本药产生很大的兴趣,相继合成大量苯駢-硫二嗪类化合物,并研究其药理作用。其中第三位及第四位碳原子經过氫化的衍生物,如双氫氯噻嗪(hydrochlorothiazide,簡称HCT),双氫三氟甲基噻嗪及苯甲基双氫三氟甲基噻嗪的利尿及利盐作用都比氯噻嗪大好几倍。这类利尿药的特点是:作用強(几与有机汞剂相当),能口服,毒性低,在治疗剂量
Since the advent of oral diuretic-antihypertensive drug chlorothiazide (CT), researchers all over the world have been interested in this medicine. A large number of benzodiazepines and thiadiazoles have been synthesized and their pharmacological effects have been studied . Hydrogenated derivatives of the third and fourth carbon atoms, such as hydrochlorothiazide (HCT), dihydrotrifluoromethylthiazine and benzhydryldihydrotrifluoromethylthiazide, Salt and salt are better than chlorothiazide several times. This type of diuretic is characterized by: a strong role (a few with organic mercury agent), can be oral, low toxicity, at the treatment dose