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目的:检测胃癌组织中CD44v6、MMP-9、VEGF表达情况及其与胃癌临床病理因素的关系,并探讨其表达与胃裸区侵犯的临床意义。方法:采用免疫组化方法测定60例胃癌组织CD44v6、MMP-9、VEGF表达情况,并结合患者的临床病理资料进行分析。结果:CD44v6、MMP-9、VEGF的表达与胃癌的TNM分期、浸润深度、淋巴结转移有关。胃裸区受侵组与未受侵组胃癌组织的CD44v6、MMP-9、VEGF的表达无明显差异。结论:CD44v6、MMP-9、VEGF的表达与胃癌的浸润转移密切相关,胃裸区是否受侵与胃癌组织的CD44v6、MMP-9、VEGF的表达无关,胃裸区这一解剖结构可能是胃癌预后较差的原因。
OBJECTIVE: To detect the expression of CD44v6, MMP-9 and VEGF in gastric cancer and its relationship with the clinicopathological factors of gastric cancer, and to explore the clinical significance of its expression and invasion of gastric naked zone. Methods: The expressions of CD44v6, MMP-9 and VEGF in 60 cases of gastric cancer were detected by immunohistochemistry and analyzed with clinicopathological data. Results: The expressions of CD44v6, MMP-9 and VEGF were related to TNM stage, depth of invasion and lymph node metastasis in gastric cancer. The expressions of CD44v6, MMP-9 and VEGF in gastric cancer tissue between invading group and non-invasive group had no significant difference. Conclusion: The expressions of CD44v6, MMP-9 and VEGF are closely related to the infiltration and metastasis of gastric carcinoma. The invasion of gastric carcinoma is irrelevant to the expression of CD44v6, MMP-9 and VEGF in gastric carcinoma, which may be the result of gastric cancer The reason for poor prognosis.