近年来大量的研究表明骨髓干细胞能够促进心肌梗死后侧支循环的形成,加快血管损伤后内皮的修复。粒细胞集落刺激因子是一类血液生长因子,近来研究发现它可以动员骨髓干细胞,使它们归巢到梗死区域,复制、分化并促进心肌的修复。本文就粒细胞集落刺激因子在心血管疾病,包括心肌梗死、血管损伤后再狭窄和心力衰竭中的作用机制及应用进行综述。 In recent years, a large number of studies have shown that bone marrow stem cells can promote the formation of collateral circulation after myocardial infarction and accelerate the repair of endothelial cells after vascular injury. Granulocyte colony-stimulating factor is a type of blood growth factor, recent studies have found that it can mobilize bone marrow stem cells, so that they homing to the infarct area, replication, differentiation and promote myocardial repair. This article reviews the mechanisms and applications of granulocyte colony-stimulating factor in cardiovascular diseases, including myocardial infarction, restenosis after vascular injury, and heart failure.