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使麻醉大鼠在5min 内失血,致使动脉血压下降至25mmHg,然后静脉注射1/10失血量的高张 NaCl 溶液(Hypertonic solution,HS,7.5%NaCl)或生理盐水(NS)。静脉注射少量 HS 能明显促进失血后血压回升,这个作用能为6-羟多巴胺或巯甲丙脯酸显著减弱,若将这两个药物同时应用,则 HS 的升压作用完全被解除。HS 使血浆 Na~+浓度明显升高,而 NS使之下降。侧脑室微量注射 HS 后也明显促进动脉血压的恢复。这些实验结果表明失血后静脉注射少量 HS 可升高血浆 Na~+浓度,高 Na~+作用于中枢神经系统,激活交感神经系统和肾素-血管紧张素系统,从而促使血压迅速恢复。
The anesthetized rats were hemorrhaged within 5 min, causing the arterial blood pressure to drop to 25 mmHg. Hypertonic solution (HS, 7.5% NaCl) or saline (NS) 1/10 of the blood loss was then injected intravenously. Intravenous injection of a small amount of HS can significantly promote blood pressure recovery after blood loss, this effect can be significantly reduced 6-hydroxydopamine or captopril, if the two drugs at the same time, the HS is completely relieved of the role of the pressure. HS plasma Na ~ + concentration was significantly increased, while NS decreased. Lateral ventricle microinjection of HS also significantly promote arterial blood pressure recovery. These experimental results show that a small amount of intravenous HS can increase plasma Na + concentration after blood loss, and high Na ~ + can activate central nervous system and activate sympathetic nervous system and renin-angiotensin system, which prompts rapid recovery of blood pressure.