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本文用形态计量学方法结合血清 F~-、骨氟含量测定研究了高(32%)、中(21%)、低(12%)蛋白质摄入对慢性低超常量氟中毒大鼠骨病变的影响。结果表明:1.饮用5ppm F~-的高氟水12个月可以诱发大鼠高氟血症和氟中毒。2.大鼠的骨氟蓄积量有随蛋白质摄入量减少而增加的趋势。3.只在低蛋白质摄入的氟中毒大鼠中诱发了有意义的骨病变。这说明低蛋白摄入会促进氟骨症的发生,高蛋白摄入则有可能减缓氟骨症的发生或减轻其严重程度。由于本实验诱发大鼠氟中毒的条件与国内一些高氟区人群饮水含氟量相近,故本文结果提示:对高氟区人群的蛋白质营养状况应予以关注。
In this paper, we studied the effects of high (32%), moderate (21%) and low (12%) protein intake on bone lesions in rats with chronic fluorosis due to fluorosis influences. The results showed that: 1. drinking high fluoride water 5ppm F ~ - 12 months can induce hyperfluorosis and fluorosis in rats. 2. The amount of bone fluorosis in rats increased with decreasing protein intake. 3. Induced meaningful bone lesions in fluorosis rats with low protein intake only. This shows that low protein intake will promote the occurrence of skeletal fluorosis, high protein intake may reduce the incidence of skeletal fluorosis or reduce the severity. Due to the experimental conditions induced by fluoride poisoning in rats and some high-fluoride areas drinking water fluoride content similar, so the results suggest that: high-fluoride areas of the protein nutritional status of the crowd should be concerned.