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目的 了解不同行为类型应激者血浆环核苷酸变化 ,为探讨心理行为因素引起冠心病的中介机制的研究提供前瞻性资料。方法 用前瞻性方法研究高考应激对高考生血浆环核苷酸含量的影响。结果 应激前 ,TABP的高考生血浆c AMP含量显著高于 TBBP的高考生 (P<0 .0 0 1) ;应激后 ,TABP和 TBBP高考生血浆 c AMP含量和 c AMP/ c GMP比值均显著降低 (P <0 .0 0 1) ,血浆 c GMP含量均显著升高 (P <0 .0 0 1)。而且 c AMP下降程度、c GMP上升程度以及 c AMP/ c GMP比值降低程度 ,TABP的高考生明显大于 TBBP高考生 (P <0 .0 0 1,P <0 .0 1,P <0 .0 0 1)。结论 高考应激对 TABP高考生血浆环核苷酸含量影响显著大于 TBBP高考生
Objective To understand the changes of plasma cyclic nucleotides in patients with different behavioral types of stress and to provide prospective data for investigating the mechanism of psychological behavior-induced coronary heart disease. Methods Using prospective method to study the effect of college entrance examination stress on the content of plasma cyclic nucleotides in college entrance exams. Results Before stress, plasma cAMP levels in TABP high test subjects were significantly higher than those in TBBP test subjects (P <0.01). After stress, plasma cAMP levels and cAMP / c GMP ratios were significantly higher in TABP and TBBP candidates (P <0.01), and plasma c GMP content increased significantly (P <0.01). Moreover, the level of c AMP decreased, the level of c GMP increased and the ratio of c AMP / c GMP decreased. The TABP candidates were significantly higher than TBBP candidates (P <0.01, P <0.01, P <0. 0 0 1). Conclusion The college entrance examination stress on plasma TABP high plasma levels of nucleotide content significantly higher than the TBBP candidates