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据巴士顿Massachusetts总医院的调查,患促性腺激素释放激素(GnRH)缺乏和并发性腺机能低下(睾丸不发育)的男性,应用雄激素能产生骨质密度增加。 Finkelstein报告,GnRH缺乏(产生于下丘脑切除者)可引起明显的骨组织不发育或骨组织丢失,以及男性早期骨质疏松症。GnRH刺激紧位于下丘脑下方的垂体前叶,释放促性腺激素,后者调节性腺的功能,促使睾丸产生雄激素睾酮。 Finkelstein等曾评价雄激素对21例患有因GnRH缺乏而引起性腺机能低下的男性患者骨密
According to a survey by the Massachusetts General Hospital in Stamford, applying androgens can produce an increase in bone density in men with gonadotropin-releasing hormone (GnRH) deficiency and concomitant hypogonadism (testicular hypoplasia). Finkelstein reports that lack of GnRH (resulting from hypothalamic resections) can cause significant bone tissue loss or bone loss, as well as early osteoporosis in men. GnRH stimulates the anterior pituitary gland immediately below the hypothalamus to release gonadotropins, which regulate the function of the gonads and cause the testicles to produce androgen testosterone. Finkelstein et al. Have evaluated the effects of androgens on bone density in 21 male patients with hypogonadism due to GnRH deficiency