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[目的]探讨舌下特异性免疫(SLIT)治疗儿童过敏性哮喘的临床效果。[方法]60例儿童过敏性哮喘患儿随机分为治疗组和对照组,对照组依据GINA(2006)方案给予常规治疗,治疗组在常规治疗的基础上给予SLIT治疗。观察治疗前后日间、夜间哮喘症状评分改变量,疗程结束后评价临床疗效,观察治疗期间的不良反应。[结果]治疗组临床疗效总有效率为93.3%,显著高于对照组(70.0%),相比较差异有统计学意义(P﹤0.05);治疗组治疗前后日间、夜间症状评分改变量均明显高于对照组,相比较差异有统计学意义(P﹤0.05);治疗组不良反应轻。[结论]SLIT治疗儿童过敏性哮喘是一种安全、有效的治疗方法,临床值得推广应用。
[Objective] To investigate the clinical effect of sublingual immunotherapy (SLIT) on children with allergic asthma. [Methods] Sixty children with allergic asthma were randomly divided into treatment group and control group. The control group was given routine treatment according to GINA (2006). The treatment group was treated with SLIT on the basis of routine treatment. Observed before and after treatment day and night asthma symptom score changes, after the end of the evaluation of clinical efficacy, observation of adverse reactions during treatment. [Results] The total effective rate of the treatment group was 93.3%, which was significantly higher than that of the control group (70.0%), the difference was statistically significant (P <0.05). The changes of the symptom scores in the treatment group before and after treatment were Significantly higher than the control group, compared with the difference was statistically significant (P <0.05); treatment group, mild adverse reactions. [Conclusion] SLIT is a safe and effective treatment for allergic asthma in children, which is worth popularizing and clinical application.