核酶（ribozyme，nz）是具有酶促活性的RNA分子，它所催化的反应主要见于核酸代谢，某些核酶还具有转肽酶和氨基酸酯酶活性。至今已研究了核酶抗HAV、HBV、HCV、HDV的作用，并发现HDVRNA自身具有核酶活性。目前设计的核酶多为锤头状结构；少部分是采用发夹状核酶（hairpinriboz Ribozyme (ribozyme, nz) is an enzymatic activity of RNA molecules, which catalyze the reaction mainly seen in nucleic acid metabolism, some of the ribozymes also have transpeptidase and amino acid esterase activity. The role of ribozymes against HAV, HBV, HCV, HDV has been studied to date and it has been found that HDV RNA itself has ribozyme activity. The current design of ribozyme mostly hammerhead structure; a small part is the use of hairpinriboz