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为探讨戊型肝炎病人血清sIL-2R水平变化及其临床意义、分别对65的戊肝病人急性期及恢复期血清进行了sIL-2R、ALT及T-Ril水平动态测定.结果显示,戊肝极期及恢复期血清sIL-2R水平均显著高于恢复期、各组间sIL-2R水平存在显著性差异(P<0.01～0.05);sIL-2R水平与同期血清ALT及T-Bil呈显著的正相关,r值分别为0.56(P<0.01)和0.38(P<0.05);戊肝极期sIL-2R水平与戊肝病程中肝功能恢复所需的时间呈非常显著的正相关, r值为0.58(P<0.01),而其下降速度则与肝功能恢复所需时间是非常显著的负相关.r值为-0.67(P<0.01).提示,细胞免疫在戊型肝炎致病中起重要作用,sIL-2R水平及动态监测可较好地反映戊型肝炎的病情变化.
In order to explore the change of serum sIL-2R level and its clinical significance in patients with hepatitis E, the levels of sIL-2R, ALT and T-Ril in acute and convalescent sera of 65 patients with hepatitis E were measured respectively.Results showed that hepatitis E Serum levels of sIL-2R were significantly higher than those in recovery stage in both polar phase and convalescent phase. The levels of sIL-2R in each group were significantly different (P <0.01-0.05). Serum levels of sIL-2R and serum ALT and T-Bil were significantly higher than those in convalescent phase R values were 0.56 (P <0.01) and 0.38 (P <0.05), respectively. The level of sIL-2R in the eutopic end stage of encephalomyelitis had a very significant positive correlation with the time required for hepatic function recovery in the course of hepatitis E, r Value of 0.58 (P <0.01), and its rate of decline and the time required for the recovery of liver function is a very significant negative correlation.r value of -0.67 (P <0.01), suggesting that cellular immunity in the pathogenesis of hepatitis E Play an important role, sIL-2R level and dynamic monitoring can better reflect the change of hepatitis E disease.