目的:探讨肺部感染对支气管封堵治疗影响的动物实验性研究。方法:取健康杂种犬18条,分为3组(A、B、C组)(n=6),经支气管镜每只犬置入致密螺栓状支气管封堵器2枚,其中A、B组为肺部感染组,C组仅为单纯封堵(A、C组封堵后使用抗生素,而B组封堵后未使用抗生素)。观察实验动物的耐受性,定期复查血象、支气管镜、胸部CT扫描,8周后观察封堵器附近支气管组织及远端肺组织变化。结果:观察期内,除1例因给药管不慎封堵入靶支气管内而死亡外,其余犬耐受性良好;截至封堵第8周,36只封堵器中,脱落共有0只(0/36)。胸部CT扫描和组织病理学检查证实,部分封堵的肺叶有萎陷,封堵部位远端肺泡腔缩小,5例封堵部位及其周围有轻度阻塞性炎症改变,未出现肺脓肿及坏死。肺部感染因素对犬的恢复有延迟;而感染组术后肌注抗生素与否,并未能缩短实验动物的不适反应过程,亦未能预防或减少阻塞性炎症的发生。结论:试制的支气管封堵器置入方便,组织相容性好;无论单纯封堵还是肺部感染组的封堵,各组实验动物均有较好的耐受性,但是肺部感染因素对犬的恢复有延迟;肺部感染组术后肌注抗生素与否,对提高动物的耐受程度无明显作用。 Objective: To investigate the experimental study of the effect of pulmonary infection on bronchial blockade. Methods: A total of 18 healthy mongrel dogs were divided into three groups (A, B and C) (n = 6). Two dogs with dense bolt-shaped bronchial occlusion were placed in each group by bronchoscopy. Groups A and B In the lung infection group, only simple occlusion was found in group C (antibiotics were used after occlusion in group A and C, and antibiotics were not used in group B after occlusion). Observed the tolerance of experimental animals, regular review of blood, bronchoscopy, chest CT scan, 8 weeks after the observation of occluder bronchial tissue and distal lung tissue changes. Results: During the observation period, all the dogs were well tolerated except for one patient who died when the catheter was inadvertently blocked into the target bronchus. As of the 8th week of occlusion, there were 0 out of 36 occluders (0/36). Chest CT scan and histopathological examination confirmed that the partial closure of the lobar collapse, distal occlusion of the alveolar contraction, 5 cases of occlusion of the site and its surrounding slight obstructive inflammatory changes, there was no lung abscess and necrosis . Pulmonary infection delayed the recovery of dogs; and intramuscular antibiotics in infected group or not, and did not shorten the process of experimental animals, the discomfort reaction, failed to prevent or reduce the occurrence of obstructive inflammation. CONCLUSION: The trial of bronchial occluder has the advantages of easy insertion and good histocompatibility. All the experimental animals have better tolerance in both simple blockage and pulmonary infection group. However, There was a delay in the recovery of dogs. The postoperative intramuscular antibiotics in the pulmonary infection group had no significant effect on improving the tolerance of the animals.