促性腺素释放激素(GnRH)静脉脉冲式注射对下丘脑机能障碍性闭经病人诱发排卵是非常成功的方法,但是应用GnRH脉冲治疗多囊卵巢病则令人满意的结果较少,其特点为排卵变化无常,妊娠率也低。本文为表明这两种反应差异的机理,作者检测了多囊卵巢(PCOD)和下丘脑性闭经两种疾病时应用GnRH脉冲对垂体和卵巢的反应。为了增进该反应,对多囊卵巢患者给GnRH脉冲治疗之前一个月,应用大剂量的促性腺素释放激素激动剂(GnRH-a),造成下丘脑性闭经的雌激素和促性腺激素低水平状态。研究分为两组,第一组为9名多囊卵巢患者,具有典型的多毛,长期未排卵,并对克罗米芬 GnRH is a very successful method of inducing ovulation in hypothalamic dysfunctional amenorrhea patients. However, the use of GnRH in the treatment of polycystic ovarian disease is less promising and is characterized by ovulation Volatile, pregnancy rates are also low. In this article, to demonstrate the mechanism of these two differences in response, we examined the response of the GnRH pulse to the pituitary gland and ovary during both PCOD and hypothalamic amenorrhea. To enhance this response, a large dose of gonadotropin-releasing hormone agonist (GnRH-a) was administered one month prior to pulsatile treatment of polycystic ovary patients with GnRH resulting in a low level of estrogen and gonadotropin in hypothalamic amenorrhea . The study was divided into two groups, the first group of nine patients with polycystic ovary, with typical hirsutism, long-term non-ovulation, and clomiphene citrate