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目的探讨血浆D-二聚体与脑卒中类型及病期之间的关系。方法运用乳胶颗粒法对354例脑卒中患者的血浆D-二聚体含量进行检测,并与正常对照组比较。结果脑卒中急性期和恢复期患者的血浆D-二聚体含量均显著高于正常对照组(P<0.01)。脑梗死恢复期患者的血浆D-二聚体含量显著低于急性期患者(P<0.05)。结论脑卒中患者存在高凝状态和纤溶功能亢进,血浆D-二聚体含量可作为观察其病情演变、判断其预后的指标。
Objective To investigate the relationship between plasma D-dimer and stroke type and disease duration. Methods The content of D-dimer in 354 patients with stroke was detected by latex particle method and compared with the normal control group. Results The levels of plasma D-dimer in acute and convalescent stroke patients were significantly higher than those in normal control group (P <0.01). Plasma D-dimer levels in convalescent cerebral infarction patients were significantly lower than those in acute phase (P <0.05). Conclusions There is hypercoagulable state and hyperfibrinolytic activity in patients with stroke. The plasma D-dimer level can be used as an index to observe the progression of the disease and judge its prognosis.