论文部分内容阅读
近年来,戊型肝炎(HE)已成为发展中国家的重要公共卫生问题,它以流行和散发形式发生,尤其在妊娠妇女中死亡率较高,其原因尚不清楚。作者应用猕猴研究戊型肝炎病毒(HEV)感染对灵长类动物孕期的影响及其是否存在垂直传播的问题。 本研究共用10只猕猴,实验组6只孕猴(怀孕早、中、晚期各2只)分别静脉注射0.5ml10％SAR-55株HEV粪悬液,含HEV约10~(5.5)ID_(50)。对照组4只(雄性和未孕雌猴各
In recent years, hepatitis E (HE) has become an important public health problem in developing countries. It occurs in a prevalent and sporadic pattern, with a high mortality rate, especially among pregnant women, for reasons that remain unclear. The authors used macaques to study the effects of Hepatitis E virus (HEV) infection on primate pregnancy and whether there is vertical transmission. In this study, a total of 10 macaques were used. Six pregnant pregnant monkeys (2 in each of the early, middle and late stages of pregnancy) were intravenously injected with 0.5 ml of 10% SAR-55 HEV excrement suspension containing 10 ~ (5.5) ID_ ). Control group of 4 (male and non-pregnant females each