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目的 :探讨血管性帕金森综合征患者血清ACLA的变化及其在发病中的意义。方法 :采用ELISA法检测 42例VP ,3 5例PD ,3 0例MCI及 3 0例正常对照组血清ACLA变化并对照分析。结果 :①VP与MCI组ACLA的IgG与IgM阳性率明显高于PD与正常对照组 (P <0 0 5 ) ;②VP组ACLA的IgG阳性率明显高于IgM(P <0 0 5 ) ;③运动障碍重 ,伴痴呆的VP患者ACLA之IgG阳性率明显增高(P <0 0 5 )。结论 :IgG型ACLA可能作为致病性抗体参与VP的发病过程
Objective: To investigate the changes of serum ACLA in patients with vascular parkinsonism and its significance in the pathogenesis. Methods: The changes of serum ACLA in 42 cases of VP, 35 cases of PD, 30 cases of MCI and 30 cases of normal control group were detected by ELISA. Results: (1) The positive rates of IgG and IgM in ACLA in VP and MCI groups were significantly higher than those in PD and normal controls (P <0.05). The positive rates of ACLA in VP group were significantly higher than those in IgM group (P <0.05) The positive rate of ACLA IgG in patients with severe obstruction and dementia was significantly increased (P <0.05). Conclusion: IgG-type ACLA may participate in the pathogenesis of VP as a pathogenic antibody