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从软珊瑚Sinularia brongersmai分得两种非萜类新细胞毒活性的精脒化合物1和2。以原料的稀醇提取物经溶剂分配处理,使活性成分集中后进行硅胶层析,甲醇-浓氨水(9:1)洗脱部分蒸馏(130°/10~(-2)mm)得到油状物,GC-MS分析表明为m/e381和383两组分的混合物(9:1)。催化氢化后变成单一的化合物2(m/e383),1和2的分子式分别定为C_(23)H_(47)N_3O和C_(23)H_(49)N_3O,结合光谱数据分析和化学降解,作者提出
Two non-terpene neocyocytotoxic spermine compounds 1 and 2 were isolated from the soft coral Sinularia brongersmai. The crude alcohol extracts were solvent-fractionated to concentrate the active ingredients and chromatographed on silica gel. Partial elution (130 ° / 10 ~ (-2) mm) of the methanol-concentrated aqueous ammonia (9: 1) gave an oil , GC-MS analysis showed a mixture of two components m / e 381 and 383 (9: 1). After catalytic hydrogenation, a single compound 2 (m / e383) was obtained. The formulas of 1 and 2 were defined as C 23 H 47 N 3 O and C 23 H 49 N 3 O, respectively. The data of combined spectroscopic analysis and chemical degradation , The author put forward