嘧啶苯芥(合520),化学名5-{对-[双-(β-氯乙基)氨基]苯氧基}尿嘧啶,是我院与有关单位协作创制成功的抗肿瘤新药。临床用于慢性粒细胞性白血病、恶性淋巴瘤、乳腺癌、鼻咽癌和睾丸肿瘤等多种癌症。作者等合成了嘧啶苯芥2-~(14)C(Ⅰ),供研究该药在体内的吸收,分布、排泄和代谢动力学等,为临床合理用药提供资料。嘧啶苯芥2-~(14)C 的合成,基本采用作者原报道的方法进行,但作了部分改进。对乙酰 Pyrimidinyl benzene mustard (together 520), chemical name 5- {p - [bis - (β - chloroethyl) amino] phenoxy} uracil, is our hospital and related units to create a successful new antitumor drugs. Clinical for chronic myelogenous leukemia, malignant lymphoma, breast cancer, nasopharyngeal cancer and testicular cancer and other cancers. The authors synthesized pyrimidinyl benzene mustard 2- ~ (14) C (Ⅰ), for the study of the drug absorption, distribution, excretion and metabolic kinetics in the body, to provide information for the clinical rational use of drugs. Pyrimidinyl benzene mustard 2- ~ (14) C synthesis, basically using the original report of the author, but made some improvements. Acetyl