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目的为探讨情感性精神障碍患者的脑形态结构变化及其与临床相关因素。方法本文对６０例情感性精神障碍患者和５８例神经症患者的脑部ＣＴ资料作对照研究，并与临床相关因素进行对比分析。结果情感性精神障碍患者中脑ＣＴ异常者２５例（４１．６７％），主要表现为脑沟增宽、侧裂池和侧脑室扩大、双额叶低密度影；对照组中脑ＣＴ无一例异常。两者比较有极显著性差异（Ｐ＜０．００５）。在２５例脑ＣＴ异常的情感性精神障碍患者中，以年龄＞５０岁、住院次数在５次以上者脑ＣＴ异常率最高。结论情感性精神障碍患者确实存在脑结构形态学改变。
Objective To investigate the brain morphological changes in patients with affective disorders and its clinical factors. Methods The brain CT data of 60 patients with affective disorder and 58 patients with neurosis were compared and analyzed with the clinical related factors. Results 25 cases (41.67%) had abnormal brain CT in patients with affective disorder. The main manifestations were enlarged sulci, lateral fissure and lateral ventricle enlargement and double-lobe low-density contrast. In the control group, there was no CT abnormal. There was a significant difference between the two (P <0.005). In 25 patients with abnormal mental CT, patients with abnormal mental function had the highest rate of CT abnormalities in patients aged> 50 years and hospitalized for more than 5 times. Conclusion There is indeed morphological changes in brain structure in patients with affective disorders.