掌跖角化过度——牙周病本综合征最初于1924年由Papillon—Lefever氏首次叙述,故又称Papillon—Lefever氏综合征。它是一种稀有的皮肤疾病和牙周组织破坏疾病,其特点是:(1)掌跖潮红、干燥,呈鳞状或皲裂,手掌角化过度呈弥漫性,病变境界很清楚,扩展到掌缘。脚底病变更为严重, Palmoplantar hyperkeratosis - periodontal disease The syndrome was first described by Papillon-Lefever’s first in 1924, it is also known as Papillon-Lefever’s syndrome. It is a rare skin disease and periodontal tissue damage disease, which is characterized by: (1) palmoplantar flushing, dry, squamous or chapped, hyperkeratosis of the hands were diffuse, the realm of the disease is very clear, extended to the palm edge. Foot disease is more serious,