论文部分内容阅读
目的探讨菰米对高脂膳食诱导脂代谢紊乱大鼠血脂及炎性因子水平的调控作用。方法44只雄性SD大鼠随机分为阴性对照组、高脂模型组、米面组和菰米组;以相应饲料连续喂养8w,测定各组大鼠体重、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)等指标。结果与阴性对照组相比,高脂模型组和米面组大鼠的血清TC、TG显著上升,HDL-C显著降低;与高脂模型组和米面组比较,菰米组的血清TC、TG显著下降,HDL-C显著升高,TNF-α、hs-CRP显著下降。结论菰米具有降低脂代谢紊乱大鼠血脂的作用,并能改善高脂血症的低度炎性状态。
Objective To investigate the regulation of blood lipids and inflammatory factors induced by high fat diet in rats induced by lipid metabolism. Methods Forty-four male Sprague-Dawley rats were randomly divided into three groups: the negative control group, the high fat diet group, the rice noodles group and the rice control group. The rats were fed with the corresponding diets for 8 weeks. The body weight, serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and high sensitivity C-reactive protein (hs-CRP) Results Compared with the negative control group, the levels of serum TC and TG and HDL-C in the high-fat model group and the mian-lian group increased significantly, while those in the high-fat model group and the mianmian group were significantly higher than those in the control group Decreased, HDL-C increased significantly, TNF-α, hs-CRP decreased significantly. Conclusion 菰 Mi has the effect of reducing lipid metabolism in rats with lipid disorders and can improve the low inflammatory state of hyperlipidemia.