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目的：为探讨胎盘５－羟色胺（５－ＨＴ）及其受体的含量与妊高征发病的关系。方法：应用免疫组织化学法和原位定量分析法，对１５例妊高征患者（ＰＩＨ组）和５例正常分娩的妇女（对照组）胎盘绒毛的５－ＨＴ及其受体进行检测。结果：对照组胎盘绒毛合体滋养层细胞及毛细血管内皮细胞的５－ＨＴ及５－ＨＴ受体免疫反应呈强阳性，妊高征组的胎盘绒毛合体滋养层细胞及毛细血管内皮细胞的５－ＨＴ及５－ＨＴ受体呈免疫反应弱阳性或阴性。原位定量分析结果显示，对照组胎盘绒毛合体滋养层细胞单位面积的５－ＨＴ及５－ＨＴ受体相对含量均高于妊高征组，两组比较，差异有极显著性（Ｐ＜０．００１）。结论：胎盘绒毛的５－ＨＴ及其受体的含量与妊高征的发病机理可能有密切关系。
Objective: To investigate the relationship between placental 5-hydroxytryptamine (5-HT) and its receptor and the pathogenesis of PIH. Methods: Immunohistochemistry and in situ quantitative analysis of 5-HT and its receptor in placental villi were performed in 15 PIH patients and 5 normal women (control group). Results: The 5-HT and 5-HT receptor immunoreactions of placental syncytiotrophoblasts and capillary endothelial cells in the control group were strongly positive. In the PIH group, placental syncytiotrophoblast cells and 5- HT and 5-HT receptors were immunoreactive weakly positive or negative. In situ quantitative analysis showed that the relative content of 5-HT and 5-HT receptors per unit area of placental trophoblastic cells in control group were higher than that in PIH group, the difference was significant (P <0 .001). Conclusion: The content of 5-HT and its receptor in placenta villi may be closely related to the pathogenesis of PIH.