目的　探讨胎盘型谷光甘肽S 转移酶 (GSTP1)在不同病变前列腺组织中的表达情况及意义。方法　将 10 0例诊断明确的前列腺标本分为五组 ,即正常组 (NP)、良性增生组 (BPH)、高级别上皮内瘤组 (HPIN)、早期浸润癌组 (PIC)及前列腺癌组(PC) ,每组 2 0例。应用免疫组织化学SP法检测GSTP1在以上五组标本中的表达。结果　GSTP1在NP、BPH、HPIN、PIC及PC组织中的表达呈逐渐降低的趋势 ,且BPH组表达明显强于HPIN组 ,HPIN组表达也明显强于PIC组 ,差异均有显著意义 (P <0 .0 1)。结论　GSTP1可能与前列腺癌发生、发展密切相关。 Objective To investigate the expression and significance of placental glutathione S-transferase (GSTP1) in prostatic tissues with different pathological changes. Methods One hundred and ten cases of diagnosed prostate were divided into five groups: normal group (NP), benign hyperplasia group (BPH), high grade intraepithelial neoplasia group (HPIN), early invasive carcinoma group (PIC) and prostate cancer group (PC), 20 cases each. Immunohistochemical SP method was used to detect the expression of GSTP1 in the above five groups of specimens. Results The expression of GSTP1 in NP, BPH, HPIN, PIC and PC tissues tended to decrease gradually, and the expression of GSTP1 in HPH group was stronger than that in HPIN group. The expression of GSTP1 in HPH group was also significantly stronger than that in PIC group (P < 0 .0 1). Conclusion GSTP1 may be closely related to the occurrence and development of prostate cancer.