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用２４小时动态心电图评价卡托普利（ＣＰＴ）、二硝基异山梨醇（ＩＳＤＮ）及其合用对无症状性心肌缺血（ＳＭＩ）的疗效。２４例有ＳＭＩ发作的冠心病患者随机分为三组。每组８例。ＣＰＴ治疗组、ＩＳＤＮ治疗组、两药合用组（ＣＴ组）。疗程为四周。结果表明，ＣＰＴ组和ＣＩ组ＳＭＩ发作次数显著减少（Ｐ＜０．０５），持续时间缩短（Ｐ＜０．０５），总缺血负荷（ＴＩＢ）减轻（Ｐ＜０．０５），缺血性ＳＴ段压低程度改善（Ｐ＜０．０５）。Ⅰ组疗效不明显。综上所述：①ＣＰＴ和ＣＰＴ与ＩＳＤＮ合用可以显著减少冠心病ＳＭＩ发作和ＴＩＢ，②ＣＰＴｇｎＩＳＤＮ合用治疗ＳＭＩ副作用少。值得临床上进一步探讨。
24-hour Holter Assessment of the efficacy of captopril (CPT), dinitroisosorbide (ISDN) and their combination on asymptomatic myocardial ischemia (SMI). Twenty-four patients with coronary artery disease with SMI were randomly divided into three groups. 8 cases in each group. CPT treatment group, ISDN treatment group, two medicine combined group (CT group). Treatment for four weeks. The results showed that the number of episodes of SMI in CPT group and CI group was significantly decreased (P <0.05), duration was shortened (P <0.05), total ischemic load (TIB) ST-segment depression was improved (P <0.05). Group Ⅰ curative effect is not obvious. To sum up: ①CPT and CPT combined with ISDN can significantly reduce the incidence of coronary heart disease and TIB SMI, ②CPTgnISDN combined treatment of SMI side effects. It is worth to further explore the clinical.