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异丙基肾上腺素(ISPR)是一种重要的邻苯二酚胺类药物,广泛用于治疗心脏疾病.然而,过量服用该药对人体非常危险.本文采用邻苯三酚红修饰多壁碳纳米管糊电极(PGRMMWCNTPE)制备了一种新型传感器,用于高灵敏度检测水溶液中的ISPR.采用计时电流法、循环伏安法和方波伏安法考察了PGRMMWCNTPE电极电催化氧化ISPR性能.通过伏安数据计算了ISPR氧化的催化反应速率常数、电子传递系数和扩散系数.在ISPR浓度0.8–570μmol/L范围内建立了线性标准曲线,检测限为0.47μmol/L ISPR.将该传感器用于尿液和药物样品中ISPR检测得到满意结果.
Isoproterenol (ISPR) is an important catecholamines, which are widely used in the treatment of heart disease.However, overdose of this medicine is very dangerous to the human body.In this paper, pyrogallol red modified multi-walled carbon PGRMMWCNTPE was used to prepare a new type of sensor for high sensitivity detection of ISPR in aqueous solution.The electrochemical oxidation of ISPR by PGRMMWCNTPE electrodes was investigated by chronoamperometry, cyclic voltammetry and square wave voltammetry Voltammetric data were used to calculate the rate constant, electron transfer coefficient and diffusion coefficient of the catalytic reaction catalyzed by ISPR. A linear calibration curve was established with an ISPR concentration of 0.8-570μmol / L with a detection limit of 0.47μmol / L ISPR. ISPR tests in urine and drug samples yielded satisfactory results.