论文部分内容阅读
目的进一步探讨和证实乳腺癌的危险因素。方法对上海市１３４名乳腺癌患者进行了１∶１配对的病例对照研究。结果月经初潮年龄、是否怀孕、初产年龄、是否哺乳、良性乳腺病、乳腺癌家族史、教育年限、行经期等危险因素与乳腺癌的发生有关。多因素条件Ｌｏｇｉｓｔｉｃ回归分析显示月经初潮年龄、初产年龄、良性乳腺病、乳腺癌家族史等因素最终进入模型。进一步对乳腺癌病人进行绝经前后的分组分析，绝经前乳腺癌的危险因素包括月经初潮年龄、初产年龄、良性乳腺病，而绝经后危险因素则包括初产年龄、行经期和体重。因素之间经检验无两两交互作用。结论提示绝经前与绝经后乳腺癌在发病上存在一定差异，但需要进一步的研究加以证实。
Objective To further explore and confirm the risk factors of breast cancer. Methods A case-control study was conducted on 134 breast cancer patients in Shanghai. Results The age of menarche, pregnancy, primiparous age, breastfeeding, benign breast disease, family history of breast cancer, educational years, menstrual period and other risk factors were related to the occurrence of breast cancer. Multivariate logistic regression analysis showed that age, age of first trimester, benign breast disease, family history of breast cancer and other factors eventually entered the model. Further analysis of breast cancer patients before and after the menopause analysis of risk factors for premenopausal breast cancer including menarche age, first trimester age, benign breast disease, and postmenopausal risk factors include the age of first trimester, menstrual period and weight. None of the two factors have been tested for interaction. Conclusions suggest that premenopausal and postmenopausal breast cancer in the pathogenesis there are some differences, but needs further study to be confirmed.