目的　研究巨大型侵袭性垂体腺瘤的临床特点及治疗方法。　　方法　回顾性分析 67例巨大型侵袭性垂体腺瘤 ,并与 2 2例非侵袭性垂体腺瘤比较。　　结果　巨大型侵袭性垂体腺瘤临床表现以内分泌紊乱多见 ,头痛、视力视野损害的发生率明显高于对照组 ,并较对照组更多出现侵犯颅外和周围脑组织引起的各种症状。CT值为 52 2Hu ;MRT1 加权呈等信号或混杂信号 ,T2 加权高信号多见 ,混杂信号次之。本组全切除加次全切除率为 61 2 % ,以扩大额下硬膜外入路及经额入路的效果较好。术后并发症和肿瘤复发率高于对照组 ,生活质量低于对照组。　　结论　巨大型侵袭性垂体腺瘤临床表现复杂 ,影像学检查信号特殊 ;提高肿瘤的全切除率及术后常规放疗是提高疗效的重要措施。 Objective To study the clinical features and treatment of giant invasive pituitary adenomas. Methods Retrospective analysis of 67 cases of giant invasive pituitary adenomas and comparison with 22 non-invasive pituitary adenomas. Results The clinical manifestations of giant invasive pituitary adenomas were more common in endocrine disorders. The incidence of headache and vision visual field damage was significantly higher than that of the control group. There were more cases of various symptoms caused by extracranial and peripheral brain tissue invasion than the control group. The CT value is 52 2Hu; MRT1 weighting is equal signal or mixed signal, T2 weighted high signal is more common, mixed signal is second. This group of total resection and subtotal resection rate of 61 2%, in order to expand the subfrontal epidural approach and the effect of the amount of the better. Postoperative complications and tumor recurrence rates were higher than those of the control group, and the quality of life was lower than that of the control group. Conclusion The giant invasive pituitary adenoma has complex clinical manifestations and special imaging examination signals. Increasing the total resection rate of the tumor and routine radiotherapy after surgery are important measures to improve the therapeutic effect.