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模仿体内环境及放射免疫显像临床应用中遇到的实际问题，观察Tg浓度、pH值及碘化钾（KI）、青霉素和地塞米松等药物对1251-抗Tg－McAb与高分化型甲状腺癌细胞结合能力的影响作用．结果显示，Tg的影响与其浓度密切相关，Tg浓度＜200ng／ml时，1251-抗Tg－McAb与高分化状腺甲癌细胞的结合率没有明显影响作用（P＞0．05）；当Tg浓度＞500ng／ml时，影响作用显著（P＜0．01）．偏酸环境可使抗Tg－McAb与高分化型甲状腺癌细胞的结合率稍低，但影响作用不大（P＞0．05），偏碱条件下，标记McAb活性损失增大，结合率显著降低（P＜0．01）．KI和青霉素加地塞米松对结合能力无任何影响．
To imitate the practical problems encountered in the clinical application of in vivo environment and radioimmunoimaging, to observe Tg concentration, pH, and drugs such as potassium iodide (KI), penicillin and dexamethasone for 1251-anti-Tg-McAb and highly differentiated thyroid cancer cells. The effect of combining ability. The results showed that the effect of Tg was closely related to its concentration. When Tg concentration was less than 200 ng/ml, the binding rate of 1251-anti-Tg-McAb and highly differentiated glandular carcinoma cells had no significant effect (P>0.05); when Tg When the concentration was higher than 500ng/ml, the effect was significant (P<0.01). Acidic environment can make the binding rate of anti-Tg-McAb and highly differentiated thyroid cancer cells slightly lower, but the effect is not significant (P>0.05), under the condition of partial alkali, the loss of labeled McAb activity increases, and the binding rate is significant. Decrease (P<0.01). KI and penicillin plus dexamethasone had no effect on binding ability.