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目的：观察米非司酮周期疗法治疗围绝经期功能失调性子宫出血（功血）患者的疗效和安全性。方法：116例围绝经期功血患者随机均分为对照组和观察组。对照组患者于诊断性刮宫后第3天给予米非司酮片10 mg，空腹服用，1次/d，连用90 d；观察组患者于诊断性刮宫后第3天给予米非司酮片10 mg，空腹服用，1次/d，连用5 d后停药，待月经来潮后第1 d起再连用5 d后停药，连续治疗3个月经周期。观察两组患者临床疗效，治疗前后雌二醇（E2）、促卵泡生成素（FSH）、促黄体激素（LH）、孕酮（P），血红蛋白（Hb）、子宫内膜厚度，治疗后月经情况、复发情况，并记录不良反应发生情况。结果：治疗后，两组患者E2、FSH、LH、P水平均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）；两组患者Hb水平均显著高于同组治疗前，子宫内膜厚度均显著低于同组治疗前，差异均有统计学意义（P＜0.05），但组间比较差异无统计学意义（P＞0.05）。观察组患者总有效率显著高于对照组，月经正常比例显著优于对照组，差异有统计学意义（P＜0.05）。两组患者功血复发率、不良反应发生率比较，差异无统计学意义（P＜0.05）。结论：米非司酮周期疗法治疗围绝经期功血患者疗效显著，可显著改善激素水平，促进正常月经周期的建立，降低子宫内膜厚度，且安全性较好。“,”OBJECTIVE:To observe the efficacy and safety of mifepristone cycle therapy in the treatment of perimenopausal dysfunctional uterine bleeding. METHODS:Totally 116 patients with perimenopausal dysfunctional uterine bleeding were randomly divided into control group and observation group. Control group was given Mifepristone tablet 10 mg from 3 d after diagnostic cu-rettage on an empty stomach for continuous 90 d,once a day. Observation group was given Mifepristone tablet 10 mg from 3 d af-ter diagnostic curettage on an empty stomach,once a day,and it was stopped after continuous 5 d. Then it continued 5 d from the first day of menstruation,and lasted 3 menstrual cycles. The clinic data was observed,including clinical efficacy,estradiol(E2),fol-licle-stimulating hormone (FSH),luteinizing hormone (LH),progesterone (P),hemoglobin (Hb),endometrial thickness,men-strual conditions and recurrence in 2 groups before and after treatment were observed,and the incidence of adverse reactions were recorded. RESULTS:After treatment,E2,FSH,LH and P in 2 groups were significantly lower than before,and observation group was lower than control group,the differences were statistically significant(P<0.05). Hb in 2 groups was significantly higher than before,endometrial thickness was significantly lower than before,the differences were statistically significant(P0.05). Total effective rate in observation group significantly higher than control group,normal proportion of menstruation were significantly better than control group,the differences were statistically sig-nificant(P0.05). CONCLUSIONS:Mifepristone cycle therapy has significant efficacy in the treatment of perimenopausal dysfunctional uterine bleeding,can significantly improve the hormone level and the establishment of normal menstrual cycle and re-duce endometrial thickness,with good safety.