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目的:探讨Ⅲ、ⅣA期鼻咽癌患者放化综合治疗的疗效和影响预后因素。方法:选取符合入组条件的Ⅲ、ⅣA期初治鼻咽癌患者156例,分为单纯放疗组(78例)和放化综合治疗组(78例)。用Kaplan-Meier方法计算生存率,用Cox比例风险模型分析预后影响因素。结果:单纯放疗组的3年总生存率为42.8%(33/78),放化疗综合治疗组为75.9%(59/78),两组比较差异有统计学意义,P=0.007。临床分期、N分期、是否化疗、治疗后是否残留是影响鼻咽癌患者生存的相关因素。结论:放化综合治疗对Ⅲ、ⅣA期鼻咽癌效果较好。
Objective: To investigate the curative effect and prognostic factors of radiotherapy combined with chemotherapy in patients with stage Ⅲ, ⅣA nasopharyngeal carcinoma. Methods: A total of 156 nasopharyngeal carcinoma patients with stage Ⅲ and ⅣA were enrolled in this study. The patients were divided into radiotherapy alone group (78 cases) and radiotherapy combined therapy group (78 cases). Survival rates were calculated using the Kaplan-Meier method and prognostic factors were analyzed using the Cox proportional hazards model. Results: The 3-year overall survival rate was 42.8% (33/78) in radiotherapy alone group and 75.9% (59/78) in radiotherapy and chemotherapy group. There was significant difference between the two groups (P = 0.007). Clinical stage, N stage, whether chemotherapy, whether residual after treatment is related to the survival of patients with nasopharyngeal carcinoma. Conclusion: Radiotherapy comprehensive treatment of Ⅲ, Ⅳ A nasopharyngeal carcinoma better.