目的 :观察血管紧张素Ⅱ (AngⅡ )对人肾成纤维细胞 (KFB)的影响。　 方法 :采用ELISA法、四甲基偶氮唑蓝 (MTT)法、流式细胞仪、免疫组织化学法分别检测AngⅡ对KFB分泌的胶原酶活性、KFB增生、凋亡、Ⅰ型胶原表达的影响。　 结果 :AngⅡ能提高KFB分泌的总胶原酶活性、促进KFB增生、抑制KFB凋亡、促进KFBⅠ型胶原的表达。　 结论 :AngⅡ能通过促进KFB增生、抑制KFB凋亡、促进KFBⅠ型胶原的表达来促进肾间质纤维化。 Objective: To observe the effect of angiotensin Ⅱ on human renal fibroblasts (KFB). Methods: The effects of Ang Ⅱ on collagenase activity, KFB proliferation, apoptosis and type Ⅰ collagen expression secreted by KFB were detected by ELISA, MTT assay, flow cytometry and immunohistochemistry respectively . RESULTS: Ang Ⅱ increased the total collagenase activity secreted by KFB, promoted the proliferation of KFB, inhibited the apoptosis of KFB and promoted the expression of type I collagen. Conclusion: Ang Ⅱ can promote renal interstitial fibrosis by promoting the proliferation of KFB, inhibiting the apoptosis of KFB and promoting the expression of KFB Ⅰ collagen.