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目的 :研究人雄激素非依赖性前列腺癌细胞对化疗药物的敏感性。方法 :采用噻唑蓝 (MTT)法测定人雄激素非依赖性高转移前列腺癌细胞 (PC- 3M)对 6种化疗药物的敏感性。结果 :PC- 3M对 6种化疗药物的敏感性依次为喜树碱 >依托泊甙 >卡铂、阿霉素、氮芥 >5 -氟尿嘧啶 (P均 <0 .0 5 )。结论 :PC- 3M对喜树碱、依托泊甙较敏感。可作为临床用药参考。
Objective: To study the sensitivity of human androgen-independent prostate cancer cells to chemotherapeutic drugs. Methods: The sensitivities of human androgen-independent highly metastatic prostate cancer cells (PC-3M) to 6 chemotherapeutic agents were determined by MTT assay. Results: The sensitivity of PC - 3M to six chemotherapeutic agents was camptothecin, etoposide, carboplatin, doxorubicin, and nitrogen mustard> 5 - fluorouracil (all P <0.05). Conclusion: PC-3M is more sensitive to camptothecin and etoposide. Can be used as a reference for clinical use.