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探讨白细胞介素－２（ＩＬ－２）在慢性肾小球肾炎（ＣＧＮ）小管间质病变中的作用。方法：采用放射免疫分析法检测３６例ＣＧＮ患者及１３例正常人血清、尿和肾活检组织ＩＬ－２含量。结果：ＣＧＮ患者肾组织和尿ＩＬ－２含量均显著高于正常对照组，并且小管间质病变愈严重，肾组织ＩＬ－２含量愈高；尿ＩＬ－２含量与肾组织ＩＬ－２含量呈高度正相关，而与血清ＩＬ－２含量无平行关系。结论：ＩＬ－２在ＣＧＮ小管间质损伤过程中可能具有重要作用，尿ＩＬ－２含量检测可反映肾局部ＩＬ－２含量变化。
To investigate the role of interleukin-2 (IL-2) in tubulointerstitial lesions of chronic glomerulonephritis (CGN). Methods: The levels of IL-2 in serum, urine and renal biopsies of 36 CGN patients and 13 healthy controls were detected by radioimmunoassay. Results: The levels of IL-2 in kidney and urine of CGN patients were significantly higher than those in normal control group, and the more serious interstitial tubulointerstitial lesions and higher IL-2 content in kidney tissue. Urine IL-2 content and IL-2 content Highly positive correlation, but not with the serum IL-2 content in parallel. CONCLUSION: IL-2 may play an important role in the process of tubulointerstitial injury in CGN. The detection of urinary IL-2 may reflect the change of IL-2 in the kidney.