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目的探讨血清癌胚抗原(CEA)、糖类抗原(CA724)联合检测在胃癌诊断中的价值。方法采用电化学发光法检测92例胃癌和45例对照者血清CEA、CA724含量。结果胃癌患者血清CEA、CA724含量、阳性率均明显高于对照组(P<0.05)。二者联合检测阳性率显著高于单项检测(P<0.05)。胃癌患者不同TNM临床分期其血清CEA、CA724含量随病变进展呈逐级递增趋势(P<0.05)。结论联合检测血清CEA、CA724可提高胃癌的检出率,对胃癌的早期诊断及预后评估有重要意义。
Objective To investigate the value of combined detection of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA724) in the diagnosis of gastric cancer. Methods The levels of CEA and CA724 in serum of 92 cases of gastric cancer and 45 cases of controls were detected by electrochemiluminescence. Results Serum levels of CEA and CA724 in gastric cancer patients were significantly higher than those in control group (P <0.05). The positive rate of the combined test was significantly higher than that of single test (P <0.05). Serum levels of CEA and CA724 in gastric cancer patients with different TNM clinical stages showed a gradual increasing trend with the progression of the disease (P <0.05). Conclusions The combined detection of serum CEA and CA724 can improve the detection rate of gastric cancer, which is of great significance for the early diagnosis and prognosis evaluation of gastric cancer.