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目的探讨血浆脂联素(APN)和D-二聚体在急性心肌梗死(AMI)患者中的变化及其临床意义。方法选择AMI患者50例,入院后均行超声心动图检查评价室壁运动和心功能,并设对照组(30例)进行比较。采用ELISA法测定APN,免疫比浊法测定D-二聚体水平。结果AMI患者APN水平显著低于正常心功能对照组(P<0.01),D-二聚体水平显著高于正常心功能对照组(P<0.01)。AMI患者APN、D-二聚体水平与左心室射血分数(LVEF)呈负相关(r=-0.549,P<0.01)。结论血浆APN、D-二聚体水平与预后显著相关,对AMI的辅助诊断、疗效观察及预后判断具有重要价值。
Objective To investigate the changes of plasma adiponectin (APN) and D-dimer in patients with acute myocardial infarction (AMI) and its clinical significance. Methods Fifty patients with AMI were selected. After admission, echocardiography was used to evaluate the ventricular wall motion and cardiac function. The control group (30 cases) was compared. APN was measured by ELISA and the level of D-dimer by immunoturbidimetry. Results The level of APN in patients with AMI was significantly lower than that in patients with normal cardiac function (P <0.01). The level of D-dimer in AMI patients was significantly higher than that in patients with normal cardiac function (P <0.01). The levels of APN and D-dimer in AMI patients were negatively correlated with left ventricular ejection fraction (LVEF) (r = -0.549, P <0.01). Conclusion The plasma levels of APN and D-dimer are significantly correlated with prognosis. It is of great value to the auxiliary diagnosis, curative effect and prognosis of AMI.